Everything below concerns heptapeptide. We keep the language plain, cite what the science says, and separate well-supported claims from open questions.
Updated 2026-05-19. Numbers and descriptions here follow the published literature rather than marketing material.
Measuring peptide exposure inside the brain is technically difficult. Selank is degraded rapidly in plasma, and assays must separate intact peptide from fragments, which favors targeted mass spectrometry over immunoassays alone. Reported half-lives are short, on the order of minutes, so effects observed hours later are attributed to downstream signaling rather than to the parent compound. Blood-brain barrier permeability is debated and rarely quantified directly. Gaps include absent dose-response characterization, inconsistent reporting of purity, and almost no pharmacokinetic data from human participants.
Selank is studied chiefly as an animal-model anxiolytic with proposed secondary effects on memory and immune signaling. Reported mechanisms include modulation of the GABA-A receptor complex, inhibition of enkephalin-degrading enzymes, and shifts in monoamine turnover within limbic structures. Some experiments describe increased expression of brain-derived neurotrophic factor in the hippocampus after repeated dosing. No single molecular target has been confirmed, and the peptide does not bind any receptor with the selectivity typical of a conventional small-molecule drug. Mechanism therefore remains a set of hypotheses rather than an established pathway.
Laboratory work relies on standard behavioral paradigms. Rodents are tested in the elevated plus maze, open field, and passive avoidance tasks, with outcomes compared against diazepam or vehicle controls. Intranasal dosing is used most often because it bypasses first-pass metabolism, though intraperitoneal and intravenous routes also appear in published protocols. Biochemical endpoints include tissue BDNF concentrations, cytokine levels, and monoamine metabolites. Human data are limited to small Russian trials reporting reduced anxiety scores; most were not prospectively registered, and few employed independent outcome assessment.
The primary structure of Selank is Thr-Lys-Pro-Arg-Pro-Gly-Pro, corresponding to the molecular formula C33H57N11O9 and a monoisotopic mass of roughly 751.9 daltons. The N-terminal threonine and the arginine residue in the fourth position are shared with tuftsin, which carries the sequence Thr-Lys-Pro-Arg. The three additional residues at the C-terminus, Pro-Gly-Pro, extend the chain and are associated with greater resistance to enzymatic degradation. This extension also separates Selank from the shorter parent peptide.
Naming conventions place Selank in the same research family as Semax, another Russian-developed peptide investigated for cognitive effects. The two compounds share a lineage but differ in sequence and in the biological systems proposed as their targets. Semax descends from ACTH fragments, whereas Selank descends from tuftsin. Publications sometimes identify Selank by its full peptide sequence or by laboratory codes rather than one uniform trade name. Because replication outside Russia is limited, reports on its properties are best read alongside the study design and the purity of the material tested.
Selank is a synthetic heptapeptide developed in Russia during the 1990s. Researchers at the Institute of Molecular Genetics of the Russian Academy of Sciences designed it as a stabilized analog of tuftsin, a naturally occurring immunomodulatory tetrapeptide. The compound has been studied primarily for its reported anxiolytic and nootropic effects. It remains largely unknown in Western pharmacology and is not approved as a medicine by major regulators such as the FDA or the EMA.
| Property | Value | Notes |
|---|---|---|
| Principal proposed target | GABA-A receptor complex | Hypothesis derived mainly from animal pharmacology |
| Common behavioral assay | Elevated plus maze | Rodent test for anxiety-like behavior |
| Reported molecular marker | Hippocampal BDNF expression | Measured by immunoassay or mRNA quantification |
| Typical dosing route | Intranasal | Chosen to reduce first-pass metabolism |
| Reported plasma half-life | Minutes | Based on limited peptide stability data |
Proposed mechanisms centre on the GABAergic system. Animal and tissue studies report changes in GABA-A receptor expression and reduced activity of GABA transaminase, the enzyme that degrades GABA. Effects on monoamine turnover, including serotonin and dopamine pathways, are also described, and a separate line of work links the peptide to increased expression of brain-derived neurotrophic factor in hippocampal tissue. Most of these findings come from rodent models and cell preparations. How the individual observations combine into a single coherent mode of action is not settled.
Pharmacokinetic data are sparse and largely derived from animal work. After intranasal administration the peptide appears in plasma within minutes, and reported half-lives are short, on the order of minutes to tens of minutes. Degradation proceeds through ordinary proteolytic cleavage into constituent amino acids and smaller fragments. Direct evidence that intact Selank reaches brain tissue in meaningful amounts is limited, and the extent of blood-brain barrier penetration is debated. Some authors argue that fragments, not the parent peptide, carry much of the observed activity.
Proposed mechanisms centre on modulation of the GABAergic system, with reports of altered expression of genes related to GABA-A receptor subunits and changed monoamine turnover. Some studies describe inhibition of enkephalinase, the enzyme that degrades endogenous enkephalins, which may prolong opioid peptide signalling. Effects on brain-derived neurotrophic factor and on cytokine expression have also been reported. These findings come largely from animal models and small human studies, and the precise primary target remains unresolved.
Published clinical evidence is limited. Most controlled trials were conducted in Russia, enrolled modest numbers of participants, and appeared in Russian-language journals, which restricts independent verification. Reported outcomes include lower anxiety scores, improved attention and memory measures, and changes in fatigue ratings. Reviews written in English note methodological limitations such as small samples and inconsistent endpoints. Whether the compound produces clinically meaningful benefit relative to established anxiolytics is therefore an open question rather than an established finding.
Selank is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It was designed at the Institute of Molecular Genetics of the Russian Academy of Sciences as a structural analogue of tuftsin, a naturally occurring tetrapeptide fragment of the immunoglobulin heavy chain. The added Pro-Gly-Pro tail was intended to slow enzymatic degradation and extend biological activity. In Russia it is registered as an anxiolytic nasal preparation, while regulators elsewhere have not approved it for clinical use.
Selank is a synthetic heptapeptide developed in Russia. Its sequence is Thr-Lys-Pro-Arg-Pro-Gly-Pro, a seven-residue chain built around the natural tetrapeptide tuftsin. Researchers at the Institute of Molecular Genetics of the Russian Academy of Sciences first described the compound in the mid-1990s. The design combined the tuftsin core with an added Pro-Gly-Pro tail, a modification intended to extend the molecule's stability in biological fluids. Published work on the peptide has appeared mainly in Russian-language journals.
Reported activity for Selank centers on anxiolytic and nootropic effects. Russian clinical reports describe use in anxiety and in cognitive or attention-related complaints. Most of this evidence comes from studies conducted by the same research groups that developed the peptide. Independent replication in other countries remains limited, and no major Western regulatory agency has approved the compound for any indication. The gap between local reports and external verification is a recurring point in discussions of the peptide.
Tuftsin, the parent structure, is a naturally occurring immunomodulatory tetrapeptide released from the Fc region of immunoglobulin G by spleen enzymes. Selank extends this four-residue sequence with three additional amino acids. The stated rationale is that the added tail slows enzymatic breakdown and may influence receptor interactions. How the full heptapeptide behaves at the molecular level is not firmly established, and proposed mechanisms often involve indirect modulation of neurotransmitter or immune signaling rather than a single defined target.
Identity and purity of selank are established with reversed-phase high-performance liquid chromatography coupled to mass spectrometry. The peptide elutes from C18 columns with acetonitrile gradients in water containing trifluoroacetic acid or formic acid, and detection is usually performed by ultraviolet absorbance near 214 nm. Electrospray ionization in positive mode gives a doubly protonated ion near m/z 377, consistent with a mass of about 752 Da. Amino acid analysis or tandem mass spectrometry of fragment ions confirms the sequence. Because the molecule has no aromatic residues, it lacks a usable 280 nm chromophore, so low-wavelength detection or mass spectrometry is required.
Peptide bonds in selank are susceptible to hydrolysis under strongly acidic or basic conditions, and the terminal proline residues are vulnerable to exopeptidase activity in biological samples. Lyophilized powder stored dry at -20 °C typically remains stable for extended periods, whereas aqueous solutions degrade faster and may lose measurable purity within days to weeks depending on pH, temperature, and microbial load. Repeated freeze-thaw cycles promote aggregation and adsorption to container surfaces. For analytical work, solutions are usually prepared fresh, kept cold, and used within a single working day.
Handling follows standard practice for research peptides. Material is weighed in a low-humidity environment because the powder absorbs atmospheric moisture. Purity is reported as the percentage area of the main peak in a chromatogram, with specifications commonly set at 95 percent or higher; values below that threshold indicate the presence of truncated or modified species. Residual trifluoroacetate from purification is often present and may affect mass balance. Certificates of analysis should state the analytical method, the column and gradient used, and the lot-specific retention time so that results can be compared across suppliers.
=== Addition of water and alcohols === Aqueous solutions of ethylene oxide are rather stable and can exist for a long time without any noticeable chemical reaction. However adding a small amount of acid, such as strongly diluted sulfuric acid, immediately leads to the formation of ethylene glycol, even at room temperature:
Michael Balint (Hungarian: Bálint Mihály; 3 December 1896 – 31 December 1970) Hungarian Jewish psychoanalyst convert to Christianity who spent most of his adult life in England. He was a proponent of the Object Relations school and author of numerous academic texts and monographs on psychiatry; was attached to the Tavistock Clinic; in 1968 Balint became president of the British Psychoanalytical Society; his wife was noted psychoanalyst and author, Enid Balint, who directed British Psychoanalytical Society (now Institute of Psychoanalysis). A volume of her papers, Before I was I: Psychoanalysis and the Imagination, was published in 1993. Simon Baron-Cohen (b.1958); clinical psychologist ; professor of developmental psychopathology at University of Cambridge; director of the university's Autism Research Centre and a Fellow of Trinity College; was knighted for services to people with autism; was awarded the Medical Research Council (MRC) Millennium Medal; He is the 2026 recipient of the Grawemeyer Award in Psychology. brother of Sacha Baron Cohen Zygmunt Bauman (19 November 1925 – 9 January 2017) highly influential Polish Jewish writer, sociologist and philosopher, writing on postmodern consumerism and liquid modernity.
Iodine will kill all principal pathogens and, given enough time, even spores, which are considered to be the most difficult form of microorganisms to be inactivated by disinfectants and antiseptics. Octenidine dihydrochloride, currently increasingly used in continental Europe, often as a chlorhexidine substitute. Peroxides, such as hydrogen peroxide and benzoyl peroxide. Commonly, 3% solutions of hydrogen peroxide have been used in household first aid for scrapes, etc. However, the strong oxidization causes scar formation and increases healing time during fetal development. Phenols such as phenol itself (as introduced by Lister) and triclosan, hexachlorophene, chlorocresol, and chloroxylenol. The fact that the more substituted and more lipophylic phenols are less toxic, less irritant and more powerful was gradually discovered in late 19th century. Nowadays comparatively more water-soluble phenols such as chlorocresol are commonly used as preservatives in personal care products while less soluble such as chloroxylenol – as topical antiseptics. Both can be encountered in household disinfectants. Quat salts such as benzalkonium chloride/lidocaine (trade name Bactine among others), cetylpyridinium chloride, or cetrimide. These surfactants disrupt cell walls. Quinolines such as hydroxyquinolone, dequalium chloride, or chlorquinaldol. 4-Hexylresorcinol, or S.T.37
A 1968 study reported that over one-third of Puerto Rican women were not aware that tubal ligation was permanent or irreversible. Some doctors did not even request consent while other doctors threatened to not deliver the baby right before delivery unless the mother consented to sterilization after birth. If mothers were receiving government assistance, many women were threatened to have their welfare terminated. Additionally, the U.S. government and institutions worked collaboratively to incentivize sterilizations. Many doctors and hospital administrators began to encourage sterilizations due to the fact that the Joint Committee for Hospital Accreditation refused to accredit hospitals in Puerto Rico "unless a ten percent limit of sterilization (in proportion to all hospital deliveries) was agreed upon". In the 1930s, Puerto Rican women began to occupy jobs within factories. The women working in these factories felt an immense amount of pressure to undergo a sterilization to prove to employers that their pregnancy would not deter them from completing their job. This same year, approximately three sugar plantations housed birth control clinics and discriminated against women that were not sterilized as they refused employment to women who would not get the procedure. Puerto Rican women on sugar plantations were discriminated against while others were incentivized to alter their reproductive capacity to become the ideal responsible and dependable female worker.
Sources: en.wikipedia.org
==== United States and Canada ==== In the United States and Canada, insects for human consumption are not classified as novel food and the import and sale is permitted. In the United States, insect food products must comply with Food and Drug Administration (FDA) standards and food labeling regulations (including allergy risk labelling). Within the Federal Food, Drug, and Cosmetic Act of 1938 (FD&C Act), the FDA states that "The term 'food' means (1) articles used for food or drink for man or other animals, (2) chewing gum, and (3) articles used for components of any such article." Thus, with insects falling under said category, they must be safe and may not bear any added poisonous or added deleterious substance that is unsafe. Said items may not be prepared, packed, or held under insanitary conditions, and must be produced in accordance with current Good Manufacturing Practice (GMP), regulations for manufacturing/processing, packing, or holding human food. The FD&C Act also includes requirements that pertain to the labeling of food and preventive controls, as applicable. Manufacturers have a responsibility to ensure that the food they produce for the United States market is safe and complies with the FD&C Act and FDA's implementing regulations. In Canada, insects are subject to the same standards and guidelines as other foods sold in stores or online.
B chromosome Any supernumerary nuclear DNA molecule which is not a duplicate of nor homologous to any of the standard complement of normal "A" chromosomes comprising a genome. Typically very small and devoid of structural genes, B chromosomes are by definition not necessary for life. Though they occur naturally in many eukaryotic species, they are not stably inherited and thus vary widely in copy number even between closely related individuals.
Left-wing groups which did not agree to the centralisation and abandonment of the soviets by the Bolshevik Party led left-wing uprisings against the Bolsheviks. Such groups included anarchists, Left Socialist-Revolutionaries, Mensheviks and Socialist-Revolutionaries. Amidst this left-wing discontent, the most large-scale events were the workers' Kronstadt rebellion and the anarchist-led Makhnovshchina in Ukraine. In 1922, the 4th World Congress of the Communist International took up the policy of the united front, urging Communists to work with rank and file social democrats while remaining critical of their party leaders, whom they criticised for betraying the working class by supporting the war efforts of their respective capitalist classes. For their part, the social democrats pointed to the dislocation and chaos caused by revolution and later the growing authoritarianism of the Communist parties after they achieved power. When the Communist Party of Great Britain applied to affiliate with the Labour Party in 1920, it was turned down. On seeing the Soviet Union's growing coercive power in 1923, a dying Lenin stated that Russia had reverted to a "bourgeois tsarist machine ... barely varnished with socialism." After Lenin's death in January 1924, the Communist Party of the Soviet Union, increasingly falling under the control of Joseph Stalin, rejected the theory that socialism could not be built solely in the Soviet Union in favour of the concept of socialism in one country.
Sources: en.wikipedia.org
Flareups continued to occur starting on June 19, sending more smoke into the air which continued to impact the local Boyle Heights community. The warehouse also experienced severe structural damage during the fire. The solar panels on the roof and the collapse of roof structure made fighting the fire difficult. On June 18, the shelter-in-place order was briefly reinstated after crews detected hydrogen fluoride, indicating that a lithium-ion battery (likely from a battery-operated forklift) had ignited inside the facility. Officials also raised concerns that the estimated 85 million pounds of frozen food (including bread, poultry, pork, and beef) inside the facility—no longer kept cold by the damaged refrigeration system—would begin to decompose, creating foul odors and potential biohazards, which Mayor Bass compared to food spoiling during a prolonged power outage. Health concerns intensified as the fire continued, with officials extending particulate matter advisories and Los Angeles Unified School District relocating students from several nearby schools due to air quality impacts. Regulatory monitors and sensors recorded improved PM2.5 levels in Central and Southeast Los Angeles, the San Gabriel Valley, and the San Fernando Valley, though air quality near the fire itself remained elevated, with "Very Unhealthy" conditions measured throughout the day in Boyle Heights; other areas ranged from "Good" to "Moderate" for PM2.5.
==== Ethanol drench ==== The alcohol used to clean the area to be branded as well as the alcohol in the coolant bath must have purities of 99%. This is because additives like water or iodine tend to create an alcohol slush at very cold temperatures. This slush is both an ineffective antiseptic and a very poor conductor of heat.
Monitoring the sky at 3, 10, 30, 100 and 300 microns, especially at 1, 3, and 10 mm, in order to identify one hundred of the most powerful sources among those observed and at each frequency; Study in detail the properties of quasars and other unusual objects; Search for monochromatic anomalies among the most powerful radio sources (such as a hydroxyl emission line), in the decimeter band; Search for periodic signals (pulsars) of interstellar origin, in the same band; Searches for monochromatic signals of different frequencies, always in the same band. According to Kardashev, only a radio interferometer with a base, either of the order of or larger than the diameter of the Earth, placed in orbital space, would allow listening to centimetric and decimetric frequencies. Once a set of unusual sources has been selected, the next step is to look for significant content in the radiations from these objects. In 1998, Nikolai Kardashev, S. F. Likhachev, and V. I. Zhuravlev proposed two SETI space projects to detect artificial sources: the Millimetron project (an orbiting observatory with a 10 m diameter mirror) and the VLBI optical telescope (for interferometric synthesis of ultraviolet, optical, and infrared images).
Acute cutaneous lupus erythematosus Atrophoderma of Pasini and Pierini (dyschromic and atrophic variation of scleroderma, morphea plana atrophica, sclérodermie atrophique d'emblée) Calcinosis–Raynaud phenomenon–esophageal dysmotility–sclerodactyly–telangiectasia syndrome (CREST syndrome) Chilblain lupus erythematosus (chilblain lupus erythematosus of Hutchinson) Childhood dermatomyositis Childhood discoid lupus erythematosus Childhood systemic lupus erythematosus Complement deficiency syndromes Dermatomyositis Ehlers–Danlos syndrome Eosinophilia–myalgia syndrome Frontal linear scleroderma (en coup de sabre, morphea en coup de sabre) Generalized discoid lupus erythematosus Generalized morphea Interstitial granulomatous dermatitis Juvenile rheumatoid arthritis (juvenile idiopathic arthritis, Still's disease) Keloid morphea Linear atrophoderma of Moulin (Moulin atrophoderma linearis) Linear scleroderma Localized discoid lupus erythematosus Localized morphea Lupus erythematosus panniculitis (lupus erythematosus profundus, lupus panniculitis, lupus profundus, subcutaneous lupus erythematosus) Lupus erythematosus–lichen planus overlap syndrome (lichen planus–lupus erythematosus overlap syndrome) Methotrexate-induced papular eruption Mixed connective tissue disease (Sharp's syndrome, undifferentiated connective tissue disease) Morphea profunda Morphea–lichen sclerosus et atrophicus overlap Mouth and genital ulcers with inflamed cartilage syndrome (MAGIC syndrome) Neonatal lupus erythematosus Nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy) Nicolau–Balus syndrome Nodulosis–arthropathy–osteolysis syndrome Normophosphatemic familial tumoral calcinosis Palisaded neutrophilic and granulomatous dermatitis Pansclerotic morphea Parry–Romberg syndrome (progressive hemifacial atrophy) Progressive systemic sclerosis Relapsing polychondritis (atrophic polychondritis, systemic chondromalacia) Rheumatoid arthritis Rheumatoid nodulosis (accelerated rheumatoid nodulosis) Rheumatoid vasculitis Rowell's syndrome Scleredema adultorum (Bushke disease, scleredema diabeticorum, scleredema adultorum of Buschke, scleredema of Buschke) Silicosis Sjögren's syndrome (Mikulicz disease, Sicca syndrome) Subacute cutaneous lupus erythematosus Systemic lupus erythematosus Toxic oil syndrome Tumid lupus erythematosus (lupus erythematosus tumidus) Tuzun syndrome Verrucous lupus erythematosus (hypertrophic lupus erythematosus) Winchester syndrome
Sources: en.wikipedia.org
Intranasal administration predominates in both animal and human research because it avoids hepatic first-pass metabolism. Injectable and intraperitoneal routes appear in animal work mainly for comparison.
Behavioral endpoints include time spent in open arms of the elevated plus maze and avoidance latencies. Biochemical endpoints include BDNF concentration, cytokine levels, and monoamine metabolite ratios in brain tissue.
Most published studies are small, originate from a limited number of laboratories, and lack independent replication. Dose-response relationships, measured brain exposure, and long-term outcomes are not well characterized.
Selank is a synthetic heptapeptide designed as a stabilized analog of the natural tetrapeptide tuftsin. It has been investigated mainly for anxiolytic and cognitive effects. It is not an approved pharmaceutical in most countries.